ISSN : 1225-0112(Print)
ISSN : 2288-4505(Online)
ISSN : 2288-4505(Online)
Research Papers : Synthesis of New 2,4-Disubstituted Thiazoles and 2-(Allylidenehydrazono)-thiazolo[5,4-b]quinoxaline Derivatives
Abstract
A series of allylidenethiosemicarbazone compounds (2a∼2e) were obtained in 45∼85% by condensing (E)-3-(aryl)acrylaldehyde (1a∼1e) with thiosemicarbazide. Theses compounds on treatment of 2,4'-dibromoacetophenone and 2,3-dichloroquinoxaline yielded 2,4-disubstituted thiazoles (3a∼3e) and 2-[(E)-3-(aryl)allylidenehydrazono]thiazolo[5,4-b]quinoxaline (4a∼4e) in good yield respectively. The structures of all the newly synthesized compounds were identified by IR and 1H-NMR spectral data.
연구논문 : 새로운 2,4-이치환된 티아졸들과 2-(Allylidenehydrazono)-thiazolo[5,4-b]quinoxaline 유도체들의 합성
초록
(E)-3-(Aryl)acrylaldehyde 유도체들 (1a∼1e)과 thiosemicarbazide 축합반응으로 일련의 알릴리덴치오세미카르바존 화합물 (2a∼2e)을 45∼85%로 얻었다. 이 화합물들을 2,4'-dibromoacetophenone와 2,3-dichloroquinoxaline로 처리하여 각각 2,4-이치환 티아졸류(3a∼3e)와 2-[(E)-3-(aryl)allylidenehydrazone]thiazolo[5,4-b]quinoxaline류 (4a∼4e)를 좋은 수율로 합성하였다. 새로이 합성한 모든 화합물들의 구조들은 IR과 1H-NMR 분광학 자료로 확인하였다.