ISSN : 1225-0112(Print)
ISSN : 2288-4505(Online)
ISSN : 2288-4505(Online)
Research Papers : Synthesis and Surface Activity of New Quaternary Ammonium Salts Prepared from 2-Chloromethyl-5-(2-Phenylthiazol-4-yl)-1,3,4-Oxadiazole
Abstract
New quaternary ammonium chlorides, [alkyldimethyl-[5-(2-phenylthiazol-4-yl]-1,3,4-oxadizol-2-ylmethyl]quaternary ammonium
chlorides (ADOQACs): 6] were obtained with high yields by the reaction of compound 5 with N,N-dimethylalkyl
amines in isopropyl alcohol. The structures and physical properties of the synthesized compounds were investigated and
those surface-active properties were measured. The surface tension (γcmc) and the minimal inhibitory concentration
(MIC) of compound 6 were found to be influenced by the number of alkyl chain carbon. Especially, compounds 6c and
6d exhibited high anti-bacterial activities and good surface-active properties.
연구논문 : 2-클로로메틸-5-(2-Phenylthiazol-4-yl)-1,3,4-옥사디아졸의 새로운 4급 암모늄염의 합성과 계면활성도
초록
새로운 4급 염화 암모늄염, {alkyldimethyl-[5-(2-phenylthiazol-4-yl]-1,3,4-oxadiazol-2-ylmethyl]quaternary ammonium chlorides
(ADOQACs): 6}을 화합물 5와 몇 가지 N,N-dimethylalkyl amine을 반응시켜 합성하였다. 합성한 화합물들의 구조와
물리적 특성을 조사하였고 계면활성을 측정하였다. 화합물 6의 표면장력(γcmc)과 최소저해농도(MIC)는 알킬기의
영향을 받은 것으로 나타났으며, 특히 화합물 6c와 6d가 좋은 항균력과 계면활성을 보였다.