ISSN : 1225-0112(Print)
ISSN : 2288-4505(Online)
ISSN : 2288-4505(Online)
Research Papers : Preparation of Vesicles Using Octasubstituted Cyclotetraphosphazene
Abstract
A cyclotetraphosphazene derivative having eight chains was synthesized from octachlorocyclotetraphosphazene, which was
employed along with cholesterol for the preparation of vesicles. The resulting vesicles were characterized by TEM and
encapsulation efficiency. The stability of the vesicles was enhanced in the presence of dihexadecylphosphate.
연구논문 : Octasubstituted Cyclotetraphosphazene으로부터 Vesicle의 형성
초록
Octachlorocyclotetraphosphazene을 사용하여 cyclotetraphosphazene 구조를 내부에 갖고 외부로 8개의 사슬 구조를 갖는
cyclotetraphosphazene 유도체를 합성하였다. 그리고 이 유도체와 콜레스테롤을 사용하여 vesicle을 형성시켰으며, TEM
을 이용해서 이 vesicle의 형태를 살펴보고, encapsulation 효율 등을 알아보았다. 이 vesicle의 안정도는 dihexadecylphosphate를
첨가함에 의해서 크게 향상되었다.