Biodegradable polymers prepared from ε-caprolactone monomer have been used in medical implants to ensure a temporarily mechanical or therapeutic function. In this work, polymer blends from hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene clycol) (PEG) were prepared with different weight ratios, e.g., 100 : 0, 90 : 10, 80 : 20, 70 : 30, and 60 : 40, using ultra sonication in methylene chloride at 65 ℃. The effect of PCL/PEG ratio on the melting point of the copolymers was investigated. As a result, it was found that the thermal properties were affected by the chain length of the PCL and PEG constituents in the copolymers. The chemical structure of each sample was measured using FT-IR and (1)H-NMR, and the surface free energy was characterized by measuring contact angles. The decomposition rate of the biodegradable polymer blends was measured from either acidiy degree by pH meter of weight loss of water. The drug release test of biodegradable polymer containing Ketoprofen was characterized by UV spectra. This showed that, the acidity, weight loss, surface free energy, and drug release of biodegradable polymers were imcreased as the PEG ratio was increased.

카프로락톤 단량체로부터 제조된 생분해성 고분자는 일시적으로 물리적인 또는 치료의 기능으로서 의료이식물로서 사용되어져 왔다. 본 연구에서는 소수성인 poly(ε-caprolactone) (PCL)과 친수성인 poly(ethylene glycol) (PEG)를 서로 다른 무게 분율로 제조하였고, 메틸렌 클로라이드에 녹여 밀봉한 후 초음파를 이용하여 교반하였다. 또 각각의 샘플들을 FT-IR 과 (1)H-NMR을 이용하여 화학적 구조를 측정하였고, 접촉각 측정으로부터 PCL/PEG 블렌드의 표면자유에너지를 구하였으며, 산도와 수상에서의 무게 감량으로부터 생분해도를 측정하였다. 한편 케토프로펜의 약물을 함침하여 조성에 따른 시편을 제작하고, 그 조성비에 따라서 약물의 방출량을 UV를 이용하여 측정하였다. 결국 산도와 무게감량, 표면자유에너지, 그리고 약물 방출량은 PEG의 조성비가 증가할수록 증가하였다.